mice think!

First essay with my new digital tablet to create new ideas!!

BBB in a neurodegenerative condition

What's happen when the Brain Blood Barrier (BBB) is in neurodegenerative condition ???. Graphique Science bring to you the model of the BBB in Alzheimer Disease!

BBB

The blood–brain barrier (BBB) is a separation of circulating blood from the brain extracellular fluid in the central nervous system (CNS).

Jak-stat signaling

He regresado de un par de congresos!!,pero finalmente creé un nuevo modelo de señalización! Con ustedes la vía de Jak-stat (con una mirada simple)!

I returned from a couple of congress! but finally I create a new model of signaling. Here is the Jak-stat pathway (in a simple view).

Frizzled Receptor

Frizzled Heptameric G Receptor with motif of PDZ interaction, CRD (cysteine-rich domain) that interact with Wnt ligands.

Long Term Potentiation (LTP)

Proceso de plasticidad sinaptica que ocurre en la región CA1 del hipocampo. La liberación de glutamato permite la activacion de los receptores AMPA y NMDA. Estos ultimos inducen la entrada de calcio permitiendo la activación de la CamKII, la cual permite la incorporacion de mas receptores a la superficie de la espina sináptica.

The synaptic plasticity in the CA1 region in the hippocampus depend of the increase in the release of the neurotransmitter glutamate to the synaptic cleft. This induces the activation of AMPA and NMDA receptors. The NMDA receptor allows the influx of Calcium activating to CamKII to induce the incorporation of new AMPA receptors to the postsynaptic membrane increase the synaptic strenght.

La plasticité synaptique dans la région CA1 de l'hippocampe dépend de l'augmentation de la libération du neurotransmetteur glutamate de la fente synaptique. Ceci induit l'activation des récepteurs AMPA et NMDA. Le récepteur NMDA permet l'afflux de calcium pour activer CaMKII pour induire l'incorporation de nouveaux récepteurs AMPA pour augmenter la membrane post-synaptique de la force synaptique.

Caenorhabditis elegans nervous system

C. elegans model of study.